Wednesday, August 31, 2011

Sony Tablet S preview

Even back when it was just a sketch we were suitably intrigued by Sony's Tablet S. Then it was the "S1," a name that, indistinct as it was, still had more character and mystery than the unfortunately generic moniker it will ship with. Still, a dull name can't obscure the most distinctive design we've yet seen in an Android Honeycomb slate, an aerofoil-like shape inspired not by a flying machine, but a rather more pedestrian folded magazine.

But, the result is a tablet that's considerably thicker than the current king of the Android hill, the Galaxy Tab 10.1 (not to mention the iPad 2), a chunky design that isn't always as hand-friendly as it looks. Is this the glossy, perfectly-paginated future of tablet design, or is it just a misshapen slate with a broken crease and shattered dreams? Read on to find out.

Note: at this time Sony was able to provide a device with final hardware, not software. So keep in mind this preview covers only the hardware, and that discussions of software and performance are liable to change.

Continue reading Sony Tablet S preview

Sony Tablet S preview originally appeared on Engadget on Wed, 31 Aug 2011 10:30:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/08/31/sony-tablet-s-preview/

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How to Boost Your Brain Power with Home ... - Health Fitness Training

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Source: http://www.healthfitnesstraining.org/how-to-boost-your-brain-power-with-home-fitness-exercise-equipment.html

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Tuesday, August 30, 2011

Debt Management Enable ? Bringing together The Debts

Complete thing . to remove debt by following simple and easy effective suggestions. Financial obligations if have a tendency to remain for a longer time that you experienced them it may request more complications and yes it gets not easy to supervise or combine them. Furthermore, you?ll find person?s that are building episodic installments nevertheless cannot fleece coat the pile of debt. However what follows is a realistic alternative that should stem the invoices in a quick approach plus the draw of the services are debt guide. This particular service is completed by personal expert. These invaluable competent person?s presume the loan condition of the borrowers and give guidance which might be sensible in deleting debt.

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Monday, August 29, 2011

Sales Training Techniques In Network Marketing

You have recently positioned yourself in either a job in sales or having to sign up with one of those thousands of network marketing companies. In addition, you are eager to get started in your new job or business venture so you have the drive to make the types of money you can make with the company.?sales training

In reality, the company that you are getting started with will put you through with an experienced sales person and learning the effective Sales Training Techniques. So, you can be more productive and generate sales and leads in a thriving company. Nevertheless, companies have invested their time in the training manuals, websites, educational tools, marketing strategies, etc. Most of the top fortune 500 Companies has a very effective training course to increase your chance for success in your chosen company.

The common mistakes new marketer makes when they first get started in MLM, they use the companies replicated website, pitching your business opportunity to your friends and family. Nonetheless, it is vital never to buy MLM leads from a broker. These Sales Training Techniques the majority of marketers won?t work for 97% of distributors in Network Marketing; it will give very little to zero results in MLM. So you need to stop listening to your sponsor in using these traditional marketing techniques to achieve success in multi-level marketing. Nonetheless, you need to be different from the thousands of marketers in the industry.?sales training online

What are the Sales Training Techniques you should learn outside from your MLM sponsor to generate sales in your company? I have often been frustrated in multi-level marketing and joined several network marketing companies. So, I thought about quitting the business at some point because I was sick and tired of pitching my business opportunity to friends and family, and also outside of my network as well.

Purchasing home-based business leads were also useless to get anybody to join me in my network marketing business opportunity. When calling your leads you are acting more like a pushy sales person and won?t convert your leads into sales. In fact, there wasn?t any duplication in my team. The thing I was doing that I was taught from my company wasn?t working.

Therefore, you want to do your due diligence and find the right company with the best Sales Training Techniques, education and leadership qualities. Nonetheless, you want to setup a business plan that has to be different than the Sales Training Techniques mentioned in this article.?sales academy

So it is a must to learn the proper Sales Training Techniques. Also you want to work with the top producers in this business and learn from them on how they got there to be in the 3% of marketers that achieve success in their company. Nonetheless, you want to avoid the mistakes brand new marketers that are taught using the traditional marketing methods that obviously don?t work.

Danny Yoon has taught thousands of people creating wealth for their own Network Marketing Business for implementing the MLM Advertising Marketing Campaigns.

Source: http://www.airlinerage.com/188/sales-training-techniques-in-network-marketing/

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Tropical Storm Jose brushing past Bermuda (AP)

HAMILTON, Bermuda ? Tropical Storm Jose spun over the open Atlantic just to the west of Bermuda on Sunday, buffeting the wealthy British territory with gusty winds and intermittent showers.

The 10th named storm of the season was passing about 80 miles (130 kilometers) northwest of Bermuda and packing winds of nearly 45 mph (75 kph), causing some storm surge in western parts of the isolated island chain. There were no immediate reports of any damage or injuries.

"The tropical storm-force winds are limited to our western marine area. They aren't actually reaching the island," meteorologist Ken Smith of the Bermuda Weather Service said.

Intermittent showers mixed with sunshine in Bermuda, which lies about 580 miles (933 kilometers) east of Cape Hatteras, North Carolina, already battered by Hurricane Irene. Many islanders headed to church in their Sunday best.

A street market popular with tourists was canceled on St. George's, but most Sunday events went on normally.

Jose, which formed early Sunday, could bring as much as 3 inches (8 centimeters) of rain to Bermuda, but there were no sustained downpours reported in the territory.

Jose was moving north at about 17 mph (28 kph), said the U.S. National Hurricane Center in Miami, Florida.

U.S. meteorologist Jeff Masters, who writes a popular weather blog, said Tropical Storm Jose will not survive long due to strong upper-level wind shear from Irene, which was swirling northward over New England toward Canada on Sunday after weakening to a tropical storm from a once-powerful hurricane.

Smith said Jose was expected to weaken into a tropical depression Monday and later dissipate.

Earlier this month, Tropical Storm Gert skirted past Bermuda, kicking up choppy seas along the island chain's coast but passing well east of the tiny British archipelago. It caused no serious damage.

Source: http://us.rd.yahoo.com/dailynews/rss/weather/*http%3A//news.yahoo.com/s/ap/20110828/ap_on_re_la_am_ca/tropical_weather

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Sunday, August 28, 2011

Fish Led Lighting | Pets at Heart


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The crappie fisherman have given the crappie some very unique names such names as calico bass,speckled perch,speckled bass,white perch,strawberry bass, and paper mouths. During the summer period white perch become less aggressive and to catch crappie you need to use some fishing savvy to locate the pole crappies and to identify crappie baits that will work best.

The papermouths are less aggressive because the natural forage such as crappie minnow fry, insects, plankton , adult crappie minnows, shiners, fathead minnows, small crayfish are plentiful and the paper mouths can be more selective on what crappie baits such as crappie crank baits, crappie jigs, crappie jigs tipped with live baits that they will attack for food. The strawberry bass have replenished their energy levels from the winter and they are attacking anything that looks live food anymore. The speckled perch are much more selective during the summer period.

The sun is high in the sky and the dog days of summer have hit the environment above the surface, but the underwater world is in high gear. ?During the summer period of the year thermo clines form in natural lakes and reservoirs. In the natural scheme of things old mother nature responds by regulating feeding time for all the different species of fish including the strawberry bass.

In some big reservoirs the big white perch will move entirely out of the shallows and into deeper water areas. The dead of summer is the best time of your to get your gear together anight fishing for crappie nd head out to the lake. You will need a good underwater fishing light and some good led powered lamps to make your night fishing trip more enjoyable. The purpose of the under water fishing light is to attract bait fish to your area and get the speckled bass started in a feeding frenzy.

The? pole crappies are nocturnal and they feed aggressively at night during the heat of the summer. A good night fishing crappie rig would consist of a slip bobber that has a small battery powered led light that attaches at the top. Place small split shot and a good crappie hook on your line next. Live crappie baits such as crappie minnows, shiners, fathead minnows, small crayfish and even fresh mussel meat work very as crappie bait at night.?

We hope the information in this article about White Crappie. We wish you the best of luck on your next fishing trip!

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Hulu's potential buyers have concerns (Reuters)

LOS ANGELES (TheWrap.com) ? Yahoo, Google, Amazon and Dish have bid or are about to bid on the video streaming site, Hulu, according to an individual with knowledge of the auction.

Other companies including DirectTV are also expected to submit non-binding bids by the deadline of this weekend, which will allow them greater access to Hulu's financials.

A handful of mainly new media companies have expressed formal interest in buying the site, which has been put up for sale by co-owners Comcast, News Corp., Walt Disney Co. and Providence Equity.

But even those companies circling the streaming service have significant questions about its value.

Bidders say that documents released thus far show that Hulu is not yet profitable, despite its rising revenues of $500 million in 2011. And the content deals in place with media providers such as CBS, NBC and the like expire in one year in some instances and do not extend longer than five years in any case.

That makes it hard for Hulu to justify its asking price of $2 billion.

"The challenge with all this over-the-top stuff is - what is the sustainable business model?" an executive at one of the bidders told TheWrap. "Are you confident that you can generate a profit?"

Hulu may be a household name, with over 1 million subscribers to its premium service and a sleek interface, but the technology isn't revolutionary enough to justify its lofty price, media executives say -- at least not without longterm content deals.

"The company's not worth that much, because it's easy to duplicate. But the content is very valuable," a media executive told TheWrap.

That's where things get tricky. Hulu's owners want to unload the site in large part because they believe they will be able to better leverage streaming rights to their movies and shows to an outside buyer.

That's become more appealing because the price for digital content has risen dramatically since Hulu launched in 2007.

The new price point has more or less been set by Netflix, which shelled out a reported $1 billion over five years for rights to programing from the cable channel Epix.

With online video growing rapidly, it stands to reason that the price for streaming rights will continue to rise. That's why Hulu's owners need to be careful that they don't lock themselves into overly long content deals with any buyer in an effort to make the site more attractive.

Give away too much and they run the risk of dulling any benefits they would reap from off-loading Hulu.

Right now the consensus seems to be that deep-pocketed Google and Amazon are the most likely to win Hulu's hand, but it's not clear that all of the partners are in agreement about the need to divest themselves from Hulu.

Disney chief Bob Iger has bluntly said that the joint venture is "committed to selling" Hulu, but other partners of the ownership group have been more circumspect.

In an earnings call earlier this month, News Corp. COO Chase Carey was less definitive, noting, "I think for us, it's still a decision to see ... what it looks like at the end. Does it make sense to pursue that path or does it make sense for us to stay in an ownership position and continue to have it driven by content owners."

Source: http://us.rd.yahoo.com/dailynews/rss/enindustry/*http%3A//news.yahoo.com/s/nm/20110826/media_nm/us_media_hulu

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Saturday, August 27, 2011

AirIndiaExpress Online Booking - Travel Planning | AuthorArticle

The service Air India Express Airlines was started in 2005 by the parent company Air India. The main purpose has been to serve the customers better and offer low cost travel to the unaffordable pockets. With stiff competition from the private players in this field the state owned company had to take some novel steps and this experiment was tried. As the name suggests, the flights are quick turn-around flights taking maximum one hour for the return journey. This service has helped boost the business of the parent company which was in doldrums and was losing passengers to the competitors.

Destinations Limited But Bound to Grow. At present, the Air India Express flights have a few destinations compared to the parent company. But the good word is that many more destinations are planned which will soon see air connectivity via Air India Express. The destinations are bound to be on the domestic front as well as the International front.

The overseas destinations constitute of those that can be reached within 4 hours. Hence, the South West Asia and South Asia are covered through this venture. The Middle East destinations are reached quickly and cost effectively via the Air India Express flights. The flights are fast and they efficiently take you there at the scheduled timings. The domestic flights too are mainly one destination flights and hence you can reach the place quickly rather than when you take a diverted flight by other airlines.

The Arty Fleet: Less In Number But High In Performance. At present the fleet is a paltry 21 of the Boeing 737 version with an average age of 2.9 years compared to the huge fleet of the mother company. It will definitely grow in the future as the demand for Air India express ticket booking is showing an upward graph. The unique feature of the Air India Express Airlines is that each one is painted on its tail with some designs that reflect the tradition of the place to where it is flying. And many a time a very common facet of the Indian culture.

Services That Are Getting Better By the Day. Compared to international standards a lot had to be said about service in Air India Airlines and its subsidiaries. But the scenario is fast changing. The affluent class is getting the worth of the money and so is the economy class. Some snacks are served as complimentary food packages on the flight and both the vegan and non-vegetarian categories are catered to with the light meals along with some light entertainment to go with it.

At present the Air India Express air fare is a major attraction to the passengers. Though, it has only Economy class, the service speaks volumes for it. The short range routes of this airline have become popular now as the travel is made quite comfortable for the passenger. The food offered is of good quality and is liked by most of the customers who have a large choice of it on board. To get Air India express tickets for the flights quickly you can book them online. Air India Express flights booking, Air India Express flights cancellation and knowing Air India Express flight schedule along with knowing Air India Express PNR status is just a cakewalk. And the bookings for the multi flights too can be done by online which is actually a big burden off of your head!

Air India Express offers world class flying experience. Go for Air India Express online Booking to fly from Kerala to Middle East and South east Asia destinations at low rates.

Author is an expert writer on travel domain, and have great experience on travel writing. To get more details on Author, visit AirindiaExpress Ticket Booking and Air indiaexpress cheap Airline Tickets

Source: http://authorarticle.com/travel-and-leisure/travel-planning/airindiaexpress-online-booking/

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The Long-Distance Relationship Survival Guide | How To Win ...

Thursday, August 25th, 2011 at 9:10 pm ?

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Skyrocketing phone bills. Layovers and missed flights. Countless hours spent pining, worrying, and wondering, Why do we do this to ourselves? Long-distance love can be one challenge afteranother, but as most committed couples will tell you, the rewards well outweigh the stresses. In this sensitive yet sensible guide, long-distance veterans Chris and Kate provide strategies for making the distance seem shorter and outline eight essential skills for relationship success:Communicating effectivelyEstablishing mutual goals and expectationsDealing with issues of trust, fidelity, and independenceHaving fun in spite of the distanceManaging time, schedules, and stressKeeping the relationship realBalancing sex and emotional intimacyMaking the transit

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Friday, August 26, 2011

Zucchini Main Course Recipes | Mr Silver Blood

Article by Zvika Kolb

Spring Risotto With Peas and Zucchini Rich and creamy, risotto is Italian-style comfort food. imported Arborio rice makes the creamiest risotto. If your market doesn?t have it, substitute medium- or long-grain white rice.

Ingredients- 2 (14 1/2 ounce) cans reduced-sodium chicken broth- 3 tablespoons butter- 1 -2 large zucchini, cut into 1/2-inch cubes (1 pound)- coarse salt- pepper- 1/2 cup finely chopped onion- 1 1/2 cups Arborio rice- 1/2 cup dry white wine- 1 cup frozen peas, thawed- 1/2 cup grated Parmesan cheese

Directions- Heat broth and 2 1/2 cups water in a small saucepan over low heat; keep warm. ? Meanwhile, melt 2 tablespoons butter in a 3-quart saucepan over medium heat, Add zucchini; season with salt and pepper. Cook, stirring often, until zucchini is golden, 8 to 10 minutes. With a slotted spoon, transfer zucchini to a plate.- Reduce heat to medium-low. Add onion; cook until soft, 5 minutes. Season with 1 teaspoon salt and 1/4 teaspoon pepper. ? Raise heat to medium. Add rice; cook, stirring, until translucent around edges, about 3 minutes. ? Add wine; cook until absorbed, about 2 minutes.- Add 1 cup hot broth at a time (stir until almost all liquid is absorbed before adding more), until rice is tender, for 25 to 30 minutes total.- Add zucchini and peas; cook until peas are bright green, 2 minutes,Remove from heat. ? Stir in remaining tablespoon butter and Parmesan. ? Serve, topped with more cheese.

Zucchini PastaThis is a great way to use up all that extra zucchini you have! Turn it into pasta! This dish is so good and easy!

Ingredients- 4 small zucchini- 2 tablespoons olive oil- 1 clove garlic, pressed- 1 (14 1/2 ounce) can diced tomatoes- 1 teaspoon oregano- 1/2 lb Italian turkey sausage, cooked and sliced- salt and pepper to taste- 1 bunch fresh basil, torn- 1/2 cup grated Parmesan cheese

Directions- Slice clean, unpeeled zucchini into ribbons, using a vegetable peeler, and turning the zucchini as you go.- Warm 1 TBSP olive oil in a saucepan, on medium heat.- Saute the garlic briefly, and add tomatoes and oregano.- Simmer uncovered for a few minutes.- Heat the remaining oil in a large skillet. Add the zucchini.Stir for several minutes, until zucchini is soft.- Add salt and pepper to taste, then mix in the sauce.- Add the sausage, stir well.- Stir in basil, and transfer to a serving dish.Top up with Parmesan cheese.

Spanish Zucchini PotFlavourful low fat Spanish dish,great over Angel Hair Pasta or your favourite pasta or rice. The key is flavor with garlic, peppers, spices added to cubed zucchini.

Ingredients- 5 medium onion diced- 3/4 Cup celery diced- 1.5 Cup bell pepper chopped (assorted red, green, yellow, jalapeno)- 8 cloves garlic (more or less to your taste)- 5 Cup sliced carrots- 3 medium zucchini cubed- 15 oz can, Spanish style stewed tomatoes, chopped ? 1 tsp fresh thyme- 2 Tbsp fresh basil- 1 tsp dry oregano- 5 Cup fresh grated Parmesan Cheese

Directions- Chop all vegetables. ? Spray a large skillet or Dutch oven size pan with lid. ? Heat pan adding onion, celery, peppers, garlic to cook for about 5-6 minutes. ? Continue to add other ingredients: tomatoes, carrots, zucchini, and spices. ? Bring to bubbling then reduce heat with lid on. ? Cook for about 30 minutes at simmering or until zucchini is done. ? Sprinkle with grated Parmesan cheese when serving.- Makes 5 servings, 1 Cup each. ? Makes a healty main dish served over pasta.

Roasted Zucchini and Yellow (Summer) SquashEasy To Cook, Tastes good hot or cold and reheats well in the microwave (We Need It Some Time).

Ingredients- 6 cups zucchini cut into large chunks- 6 cups yellow squash cut into large chunks- 2 tbsp olive oil plus extra for greasing pan- 1 tsp garlic powder- 1 tsp salt- 1 tsp ground black pepper

Directions- Preheat oven to 450F degrees.- Grease roasting pan with olive oil- Chop zucchini and yellow squash and put into large bowl.- Drizzle olive oil over squash. Mix with a large spoon until squash is evenly coated. ? Sprinkle garlic powder, salt, and pepper over squash. Mix with a large spoon until squash is evenly coated.- Pour squash onto roasting pan and spread it out until it evenly covers the pan.- Bake for 15-20 minutes stirring once until cooked through.- Makes 12 one cup servings but we usually eat 2 cups at a meal.

Zucchini And Tomatoes Dishso good! Zesty and spicy and very tasty. The tomatoes really add to the flavour.

Ingredients- 1 large fresh zucchini- 1 can tomatoes seasoned with basil garlic & oregano- 1 medium onion, chopped fine- 1 clove garlic, minced- low-fat Parmesan cheese- 1/4 teaspoon garlic salt, with parsley seasoning ? fresh basil- fresh oregano- salt and pepper- Pam butter-flavored cooking spray

Directions- finely chop the onion.- Slice the zucchini (not to thick).- Saut? the zucchini with the onion, garlic.Add all your seasoning?s.- Saut? this for a few minutes in a pan sprayed with butter pam.- Do not saut? too long as you do not want the zucchini soft.- Add the tomatoes and simmer few minutes.- Remove from heat and serve on plates adding Parmesan cheese on top.

Stuffed Zucchini With Ham & CheeseA great summer side dish. Use medium-sized zucchini. You can prepare zucchini for baking up to 1 day ahead. Keep covered and refrigerated.

Ingredients- 3 tablespoons olive oil, divided- 1 1/2 cups chopped onions- 3 garlic cloves, minced- 4 ounces lean smoked ham, minced- 1 cup fresh breadcrumb- 1 cup freshly grated parmesan cheese, divided- 1/2 cup chopped Italian parsley- 1 large egg (beaten)- 8 medium zucchini, horizontal top cut off

Directions- Heat 1 oil tablespoons in a heavy large skillet over medium heat. Add onion and garlic. ? Saute until onion is soft and golden, about 9 minutes. ? Transfer onion mixture to medium bowl. ? Stir ham, breadcrumbs, 1/2 cup cheese, and parsley into onion mixture. ? Season stuffing to taste with salt and pepper. ? Stir in egg.Brush 13x9x2? glass baking dish with oil. ? Using melon baller or teaspoon, scoop pulp from zucchini, leaving 1/4? thick shell. Fill zucchini shells with stuffing; arrange in dish. ? Drizzle with 2 tablespoons of oil. Sprinkle with 1/2 cup cheese.- Bake in A preheated 350F degree oven uncovered for 40 minutes. ? Increase heat to 400F degrees. Bake until tender and beginning to brown, about 15 minutes.

Zucchini Lasagna (Lasagne) Wow, It?s tender and sweet and plain appetizing! My choosy kid LOVED it! Great for anyone going on low carb

Ingredients- 2 1/2 cups zucchini, sliced 1/4 inch thick(about 2 medium)- 1/2 lb lean ground beef ? 1/4 cup onion, chopped- 2 small tomatoes, cut up- 1 (6 ounce) can tomato paste- 1 garlic clove, minced- 1/2 teaspoon dried oregano- 1/2 teaspoon dried basil- 1/4 teaspoon dried thyme- 1/4 cup water- 1/8 teaspoon pepper- 1 egg- 3/4 cup low fat cottage cheese (or low fat or fat free ricotta)- 1/2 cup mozzarella cheese, shredded ? 1 teaspoon flour

Directions- Cook zucchini until tender, drain and set aside. ? Fry, meat and onions until meat is brown and onions are tender; drain fat. ? Add next 8 ingredients and bring to boil.- Reduce heat; simmer, uncovered for 10 minutes or until reduced to 2 cups.- In a small bowl slightly beat egg.Add cottage cheese, half of shredded cheese and flour.- In (1 1/2-qt.) baking-roasting pan arrange half of the meat mixture. ? Top with half of the zucchini and all the cottage cheese mixture. ? Top with remaining meat and zucchini.- Bake uncovered at 375 degrees F for 30 minutes.- Sprinkle with remaining cheese. ? Bake 10 minutes. Let stand 10 minutes before serving.

Thai Zucchini DishThere are intriguing flavor combinations of this Thai cuisine dish. The mild zucchini is a perfect partner for the stronger flavors in this dish.

Ingredients- 1 garlic clove, minced- 1 teaspoon minced fresh ginger- 1 pinch dried crushed red pepper flakes- 2 teaspoons olive oil- 1/3 cup finely chopped unsalted dry roasted peanuts- 3 teaspoons chicken broth- 3 teaspoons rice vinegar- 2 teaspoons soy sauce- 1 pinch sugar- 3 medium zucchini, cut into very thin strips

Directions- Cook garlic, ginger, and red pepper in oil in a large skillet over medium-high heat for 1 minute, stirring constantly.- Add peanuts and next 4 ingredients, stirring well.- Add zucchini, and cook, stirring constantly, for about 5 minutes, or until crisp tender.- Serve immediately.

Roasted Zucchini With ThymeMade this tonight for a early dinner and so glad I tried it. I have fried zucchini this summer and grilled it but wanted to try something different. Came across this recipe and loved it.

Ingredients- 3 zucchini, quartered and cut into chunks- 1 onion, sliced- 2 tablespoons olive oil- 1 teaspoon thyme- salt & pepper

Directions- preheat oven to 450F.- toss zucchini, onions, salt, pepper ,thyme and olive oil on a baking sheet.- roast 30 minutes, stirring halfway through.

Top Zucchini and Ground Beef Skillet-StoveEasy, Healthy, One Pot Meal. It Works Great With A Head Of Chopped Cabbage Also. You Can Also Try To Serve It With Cottage Cheese.

Ingredients- 1 lb lean ground beef or 1 lb ground turkey- 2 lbs medium zucchini, approx. 9, cut in 1/4-inch half circles- 1 green bell pepper, chopped- 1 large white onion, chopped- 2 garlic cloves, minced- 1 (26 ounce) jar spaghetti sauce, your choice- 1 teaspoon garlic powder- 1 teaspoon dried sweet basil leaves- 1/2 teaspoon ground black pepper- salt

Directions- Brown ground beef with onion and bell pepper in a large skillet or pot with lid. ? Drain grease. Add garlic and seasonings. Stir. ? Add zucchini and stir. Cover with lid and cook over medium heat for approximately 15 minutes until the zucchini is crisp tender (I don?t add any water, the zucchini has enough). ? Stir about every 5 minutes. ? Remove lid and stir in spaghetti sauce. ? Cook for another 5 minutes. ? Great served with cottage cheese or topped with parmesan!

Author Name : Zvika KolbVisit Our WebSite For More Great Zucchini Recipes.

Source: http://www.mrsilverblood.com/zucchini-main-course-recipes.html

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Wednesday, August 24, 2011

Springpad Now Categorizes And Saves Your Facebook Friends? Likes

Springpad_ a free app that helps you rememberEvernote rival Springpad is releasing a nifty new feature today, allowing users to discover the likes, check-ins and recommendations of all of your Facebook friends. So you'll be able to see the movies, television shows, books, music and places your friends recommend in one place. For background, Springpad's multi-platform digital notebook allows you to jot down notes, save websites, images and more. Springpad will then categorize your saved content, and allows you to share your notes, set reminders and more. The app goes a step further to analyze your content and then serve you alerts to relevant news, offers and deals. Springpad's semantic data technology allows you to save products, books, movies, recipes and more, and automatically get enhanced information, including price drops, local availability and coupons.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/-xY2q7iYkyE/

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I need some info on foster care when the child is being fostered ...

Q???t??n b? runfree925: I need ??m? info ?n foster care wh?n th? child ?? being fostered b? a biological family member.?
Wh?n a child ?? ?n foster care, b?t ?? being fostered b? ?n aunt ?r uncle ?f th?r? biological family, ?? th? child allowed t? b? m???d fr?m home t? home within th? family ???r? week/weekend? Or ?? ?t regardless ?f wh? th? child ?? being fostered out t?, within family ?r a ?tr?ng?r, th? child m??t stay w?th th? foster parents 24/7 t? insure stability ?nd security ?n th? child?s mind/life?

Best ?n?w?r:

An?w?r b? Sam
Th? child ??nn?t b? ?m???d? weekly. Y?? ??n l?t th?m g? ?n visits ?? th? case worker approves, ?t?s n?t l?k? ??? w??ld never g?t a br??k.

Wh?t d? ??? th?nk? An?w?r below!

This entry was posted in Life Insure and tagged Being, biological, Care, child, family, foster, fostered, info, member, need, some. Bookmark the permalink.

Source: http://www.getaffordableinsurance.net/i-need-some-info-on-foster-care-when-the-child-is-being-fostered-by-a-biological-family-member/

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Tuesday, August 23, 2011

Small molecules shed light on cancer therapies

Tuesday, August 23, 2011

Patients suffering from an aggressive brain cancer will benefit from the results of a University of Illinois study that could advance the development of targeted gene therapies and improve prognosis.

"We have advanced the understanding of the role of microRNAs on glioblastoma multiforme, a deadly brain cancer, by studying the networks between the microRNAs and their target genes associated with different stages of cancer development and progression," said Kristin Delfino, a U of I doctoral candidate in animal science with a focus in genetics and bioinformatics.

What exactly are microRNAs? microRNAs are small, non-coding RNA molecules that regulate the expression of genes such as oncogenes or tumor suppressor genes. U of I researchers used a novel approach to identify the simultaneous association between tens of thousands of microRNAs, target genes, and glioblastoma progression and survival.

Delfino integrated clinical information such as race, gender, therapy, survival, and cancer stage from 253 patients together with genome-wide microRNA and gene expression data.

"We looked at the big picture and how microRNAs work together," Delfino said. "When you look at a single microRNA alone, it can seem significant. But when you evaluate it in the context of all other microRNAs, some turn out to be more significant and others may not be as significant as they appear on their own. The systems biology approach that we implemented is critical for understanding the gene pathways influencing cancer."

The study evaluated 534 microRNAs together, unlike the typical method of studying one at a time. They confirmed 25 microRNAs previously associated with glioblastoma survival and identified 20 other microRNAs associated with initiation or growth of other cancer types such as breast cancer, ovarian cancer and gastric adenocarcinoma.

"These findings suggest common pathways that can be targeted with similar drugs already developed and tested for other cancers," said Sandra Rodriguez Zas, co-researcher and U of I professor of animal science and bioinformatics.

In addition, researchers found that some of the microRNA biomarkers of survival are personalized, Rodriguez Zas said. This means that they are particularly useful for patients of a specific race, gender or therapy. Other microRNAs are equally effective regardless of the clinical conditions of the patient.

"These biomarkers can serve as the basis to dig deeper into cancer studies," Delfino said. "Cancer affects us all in one way or another. Unfortunately, we still don't know how it's caused, what takes place when it is caused and how to cure it. But these biomarkers give us guidance into developing specific gene therapies to target glioblastoma."

Today patients can easily and cheaply be screened for microRNA and target gene levels, Rodriguez Zas said.

"Based on our research, that information can be used to select the most effective therapy and develop prognosis strategies," Rodriguez-Zas said.

###

This study, "Therapy-, Gender- and Race-specific microRNA Markers, Target Genes and Networks Related to Glioblastoma Recurrence and Survival," was published in Cancer Genomics & Proteomics. Co-researchers include Kristin Delfino, Nicola Serao, Bruce Southey and Sandra Rodriguez Zas, all of the U of I.

University of Illinois College of Agricultural, Consumer and Environmental Sciences: http://aces.illinois.edu/

Thanks to University of Illinois College of Agricultural, Consumer and Environmental Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 15 time(s).

Source: http://www.labspaces.net/112668/Small_molecules_shed_light_on_cancer_therapies

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Kaspersky Internet Security 2011 1 User 1 Year Retail DVD Box (UK)

Kaspersky Internet Security 2011 1 User 1 Year Retail DVD Box (UK) Kaspersky Internet Security 2011 1 User 1 Year Retail DVD Box (UK) Kaspersky Internet Security 2011 has everything needed to stay safe and secure whilst surfing the web. It provides constant protection for all users and their families ? whether they work bank shop or play online. This latest product from Kaspersky Lab will even protect the user from as yet unknown threats using the optimised combination of proactive behavioural and in-the-cloud technologies. Unique Safe Surf technology will prevent the user from visiting harmful or offensive websites while Virtual Keyboard and anti-phishing tools will keep their digital identity secure. With Kaspersky Internet Security 2011 users will always stay ahead of the threats Features Risk-based Application Control restricts programs? rights to access potentially vulnerable system resources or share sensitive data on the Internet System Watcher - Heuristics-based analysis monitors restricts and blocks suspicious program behavior Safe Run mode launches questionable applications and websites without risk Rescue CD disinfects the system after malware attacks Safe Run for websites mode provides added security for online banking and other similar activities where a high risk of identity theft exists Improved: Advanced antimalware technologies even allows installation on infected PCs New System Watcher technology tracks records and analyzes suspicious activity and lets you roll back any dangerous actions Safe Surf technology blocks malware and phishing websites for great online security Protection Anti-Phishing: Yes Two-Way Firewall: Yes Anti-Spam: Yes System Requirements Minimum Processor Requirements: 800 MHz or higher for Windows XP • 1 GHz 32-bit (x86)/64-bit (x64) or higher for Windows Vista/7 Minimum Memory Requirements: Windows XP 512MB • Windows Vista/7 1024MB Minimum Storage Requirements: 480MB Operating System Requirements: Microsoft Windows XP Home Edition (Service Pack 2 or higher) • Microsoft Windows XP Professional (Service Pack 2 or higher) • Microsoft Windows XP Professional x64 Edition (Service Pack 2 or higher) • Microsoft Windows Vista Home Basic (32/64 Bit) • Microsoft Windows Vista Home Premium (32/64 Bit) • Microsoft Windows Vista Business (32/64 Bit) • Microsoft Windows Vista Enterprise (32/64 Bit) • Microsoft Windows Vista Ultimate (32/64 Bit) • Microsoft Windows 7 Starter (32/64 Bit) • Microsoft Windows 7 Home Basic (32/64 Bit) • Microsoft Windows 7 Home Premium (32/64 Bit) • Microsoft Windows 7 Professional (32/64 Bit) • Microsoft Windows 7 Ultimate (32/64 Bit) Peripherals: Computer Mouse Miscellaneous: CD/DVD Drive for installation of the program from CD ROM • Microsoft Windows Installer 2.0 • Internet connection for product activation • Microsoft Internet Explorer 6 or higher Licensing Subscription Period (Years): 1 Version: 2011 Product Type: Disk Kit Subscription Term: 1 Year User Licences: 1 licence/s Package Type: DVD Jewel Case Product Distribution Type: CD-ROM

More information

Source: http://www.covelo.org/kaspersky-internet-security-2011-1-user-1-year-retail-dvd-box-uk/

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Monday, August 22, 2011

Researchers find gene variants tied to prostate cancer ...

August 21, 2011 by Smile Research

Researchers find gene variants tied to prostate cancer

18/08/2011 -
International researchers have found five gene variants strongly linked to aggressive prostate cancer, a discovery that could lead to new tests and treatments, a study says.
click here

Prostate cancer is the second deadliest among men after lung cancer, but doctors have long puzzled over why some tumours turn deadly while others can be monitored for years without much growth.

This uncertainty has led to questions about the value of screening, when some men are ?over-treated? for tumours that were not life-threatening and may face side effects such as loss of sexual function and bladder control problems.

The findings by the US-Swedish team could transform how prostate cancer is treated by helping doctors identify a subgroup of people whose tumours are more likely to kill them and targeting their tumours accordingly.

Early therapy for prostate cancer can cost up to $US3 billion ($A2.86 billion) per year in the United States, said the study in the September issue of Cancer Epidemiology, Biomarkers & Prevention published on Tuesday.

?While previous studies have suggested that genetic background influences prostate cancer outcomes, this is the first study to validate genetic markers associated with lethal disease,? said lead author Janet Stanford of the Fred Hutchinson Cancer Research Center in Seattle.

The five markers ? LEPR, RNASEL, IL4, CRY1 and ARVCF ? are single-nucleotide polymorphisms, or SNPs, DNA variations that may be linked to disease.

?We chose to study SNPs in genes that potentially play a key role in biological pathways that may contribute to prostate cancer progression such as inflammation, steroid-hormone production and metabolism, DNA repair, circadian rhythm and vitamin D activity,? Stanford said.

Researchers analysed DNA in blood samples from 1,309 Seattle-area prostate cancer patients aged 35 to 74 at the time of diagnosis.

They found 22 SNPs that were ?significantly associated with prostate cancer-specific mortality,? according to the study.

Further examination of the 22 SNPs in a Swedish group of cancer patients with the same age parameters narrowed down the five SNPs that were most closely linked to death from prostate cancer.

?Patients who carried four or all five of these genetic markers had a 50 per cent higher risk of dying from their prostate cancer than patients who had two or fewer,? said the study.

?The risk of dying from prostate cancer increased with the number of SNP genetic variants a patient carried.?

Prostate cancer kills about 32,000 men in the United States each year, but is the most commonly diagnosed of all male cancers with 240,890 new cases each year, said the National Cancer Institute.

More studies are planned to examine other patient populations.

African-Americans are twice as likely to die from prostate cancer as whites, according to the NCI, which noted that the disease is common in North America and northwestern Europe, but less so in Asia and South America.

Source: AAP NewsWire

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Source: http://profncampbell.wordpress.com/2011/08/21/researchers-find-gene-variants-tied-to-prostate-cancer/

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Sunday, August 21, 2011

noah - Articles 20VN | What's the Real Deal with Personal Growth ...

Everybody has an opinion. But it is probably safe to say that all of us recognize that personal growth represents a road of expansion. Whether we search for inner peace, more fulfillment and success, or are interested in creating a simpler life, we have embraced the benefits of personal growth. In fact, this specialized market of self improvement, spirituality, and overall wellness has exploded into all areas of our culture. No matter what you're trying to improve, there are books, DVD's, and a slew of professionals revealing their guidelines for personal growth.

The obvious advantages are that we become more self-reliant, more responsible, and live within a framework of higher standards-those that reflect authenticity and integrity. The less-highlighted, but more impacting benefit that results from a dedicated commitment is that we become more responsible toward others. What? Personal growth is not all about me?

No it's not. When done well, personal growth ends up incorporating a better you so that the better you can integrate better with others. It means we begin to develop an ability to consider and understand how OTHERS think and feel along with the ability to care-even if we disagree. It means we become able to go past ourselves as individuals and become adept at being part of the collective. That usually means dropping the ego which either insists on imposing and proving itself right, or building enough defenses to appear beyond reproach.

The pitfalls of personal growth are seldom discussed. We may confuse our getting to know ourselves better as a sudden ability to defy those around us by blaming and becoming confrontational, or by translating our self-indulgence into self-empowerment when we demonstrate that we can and must take care of "me" first. The constraints of the ego keep us bickering about our way of thinking and doing. These constraints disallow us from seeing past our own noses, thus making us unable to grasp concepts like forgiveness and tolerance, let alone humility. It is at this point that we forget all about personal growth.

However, when we strive to improve anything about ourselves, the result is heightened awareness of who we are, how we really think and feel, and how individual that truly is. That leads to better decision-making because we develop self-respect. When all of that comes together we suddenly gain insight that it is imperative to extend EXACTLY the same to others. Why? Because ALL of our perceived problems result from digging our heels in about what we think we have experienced. Our survivor instinct tells us to protect ourselves by creating perfectly packaged reasoning of why people and things are the way they are, why we can't affect them, and just like that, we are responsible for nothing-except to serve the selfish needs of our ego. Our problems are exiled and we can move on to our perfectly organized lives.

We should remember that when we make our needs equal to those of anyone else, we eliminate the repetition of negative behavioral patterns that keep us stuck and unable to move on. If we seek out personal growth and truly learn to change ourselves and our behavior with others in mind, all that we do improves all that is around us-because more than "me" begins to matter.
Challenge yourself to demonstrate that you have grown as an individual by relinquishing any given perspective, in any given situation, to that of someone else's. You will most certainly be surprised with the result and wonder what it was that took you so long to even try.

Is this the only thing you need to do to improve your life? Hardly, but it's a challenge worth taking!

Source: http://www.20vn.com/personal-growth/what-s-the-real-deal-with-personal-growth-4b5.htm

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Source: http://bedytog.livejournal.com/17189.html

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City of Englewood to administer its own income tax collection

Photo by Marilyn McConahay

Accepting a proclamation for Grace Brethren Village from Englewood Mayor Pat Burnside, third form left, are, left to right: Elnora Schopp, Administrator Mike Montgomery, Burnside, Faith Shock, Linda Geaslen and Executive Director Gene A. Geaslen.


Photo by Marilyn McConahay

Englewood Mayor Pat Burnside presented a proclamation to Happy Corner Brethren Church. Flanking Burnside, third from left, are: accepting the proclamation are, left to right: Jane Woodie, Pastor Kelly Meyerhoeffer, Jan Weaver, Carol Blouch and Jim Oren.


By Marilyn McConahay

For the Independent

mp.mcconahay5@gmail.com

The City of Englewood has decided to administer its municipal tax collection locally, thus ending a temporary December 2002 contract with the City of Vandalia to perform that service. The temporary arrangement was in place while the city explored alternative methods of local income tax collection.

City Council approved legislation at its Aug. 9 meeting to terminate the contract with Vandalia and City Manager Eric Smith was empowered to begin the process of establishing a division of income tax under the city?s department of finance.

Smith said the new method of handling the local income taxes should be up and running by Dec. 30.

?We have studied the feasibility of assuming control of administering and collecting our local income taxes and this is what we have decided to do,? Smith said.

In addition to ending the agreement with Vandalia, the process involves increasing the number of city positions by adding an income tax administrator and a finance clerk; purchase of software from Creative Microsystems Inc. and contracting with the Cleveland Collection Agency to collect delinquent taxes.

Council approved separate legislation authorizing all of those related actions.

?Council also will need to appoint three citizen members to the Board of Tax Appeals,? Smith said.

In other legislation, Council authorized taking action to remedy a blight situation at properties located at 509 and 305 Wolf Avenue and at 213 Tate Avenue, where owners have not complied with repeated notification by the city to clean up their properties.

Notices of Violation were sent to the property owners on July 28, giving them seven days to make necessary repairs, but none were made, Smith said.

The City will take action by trimming overgrown bushes and trees, repairing broken gutters and removing debris from the properties.

The property owners later will be assessed for these services on their tax bills, Smith said.

Mary Grilliot, who with her husband, Bill, owns and operates Company 7 BBQ, located at Main Street and Wenger Road in Englewood, appeared before Council to begin a dialogue with the city about changing its regulations regarding electronic message board promotional signs.

Grilliot would like to see a change in the regulation requiring 10 minutes between changes in promotional messages, citing other signs in the area that change every two seconds. She said it would allow her to use larger letters instead of having to cram several specials onto the board at once.

Smith said the 10-minute pause regulation was designed to prevent a ?Las Vegas atmosphere.?

?We?re delving into new territory with the changeable electronic signs. There are more and more of these signs, not just in Englewood, but throughout the country,? Smith said. Grilliot said that she has done extensive research regarding the signs.

?The questions are ?Will it cause traffic accidents and will it be too glitzy??? she said. ?In the absence of research, caution is justified. With research, it may be time to look into it.?

?Many sign boards have incredible impact on business volume ? 25 to 50 percent in an SBA survey, which has an impact on jobs and sales and profits,? she continued.

Smith is in agreement that the city should revisit the regulation.

?I think she?s right. We need to take a look at it. This would eventually get to Council, but first it will go the Planning Commission,? he said.

?Since she provided information to city staff, they can review it and provide input to the Planning Commission, who will make a recommendation to City Council,? Smith said.

Mayor Patricia Burnside presented two proclamations during the meeting.

The first was to Grace Brethren Village, a retirement community located at 1010 Taywood Road, as part of its celebration of 40 years of service to seniors in Englewood and surrounding areas.

The proclamation says that according to a 2010 Ohio Department of Aging survey, Grace Brethren Village scored highest in resident satisfaction it the Dayton area. It also has a five-star designation from the Center of Medicare/Medicaid Services.

On hand to accept the proclamation were Elnora Schopp, Faith Shock, Linda Geaslen, Executive Director Gene A. Geaslen and Administrator Michael Montgomery.

The other proclamation was presented to Happy Corner Church of the Brethren on celebrating 200 years as a separate congregation. The church was commended for serving a no-cost meal on Monday nights that is open to anyone and for partnering with other area churches to provide food items to Northmont FISH.

Accepting that proclamation were Jane Woodie, Pastor Kelly Meyerhoeffer, Jan Weaver, Carol Blouch and Jim Oren.

Source: http://www.englewoodindependent.com/2011/08/city-of-englewood-to-administer-its-own-income-tax-collection/

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Saturday, August 20, 2011

Labor groups differ over US-Canada oil pipeline

Secretary of State Hillary Rodham Clinton shakes hands with Canadian Foreign Minister John Baird at the State Department in Washington, Thursday, Aug. 4, 2011. (AP Photo/Jacquelyn Martin)

Secretary of State Hillary Rodham Clinton shakes hands with Canadian Foreign Minister John Baird at the State Department in Washington, Thursday, Aug. 4, 2011. (AP Photo/Jacquelyn Martin)

Secretary of State Hillary Rodham Clinton, speaks during a bilateral meeting with Canadian Foreign Minister John Baird, not pictured, Thursday, Aug. 4, 2011, at the State Department in Washington. (AP Photo/Jacquelyn Martin)

Canadian Foreign Minister John Baird listens during a bilateral meeting with Secretary of State Hillary Rodham Clinton, not pictured, Thursday, Aug. 4, 2011, at the State Department in Washington. (AP Photo/Jacquelyn Martin)

(AP) ? A Canadian company's plan to pipe oil from Alberta to the U.S. Gulf Coast is pitting traditional Democratic allies against each other.

Two unions said Friday they oppose the 1,700-mile Keystone XL pipeline. That opposition aligns them with environmentalists but pits them at odds with the Teamsters, one of the largest and most influential unions.

The Transport Workers Union and the Amalgamated Transit Union say they're concerned that the $7 billion pipeline could pollute groundwater and cause health problems near the Texas refineries where the oil will go.

Teamsters' chief economist James Kimball says the project would create thousands of construction jobs at a time of high unemployment.

Calgary-based TransCanada says it has agreements with four international unions to build the pipeline.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-08-19-Oil%20Pipeline/id-7443596454bb471683837798cb56724b

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HBO reworks film in wake of West Memphis 3 verdict (Reuters)

LOS ANGELES (Reuters) ? Premium cable TV network HBO plans to re-tool the ending of the third in a series of documentaries it has backed on the "West Memphis Three," reflecting Friday's decision to free the men previously convicted of murder.

Damien Echols, Jason Baldwin and Jessie Misskelley Jr. pleaded guilty in an Arkansas courtroom on Friday to the gruesome, 1993 murders of three young boys, but in an unusual bargain with prosecutors, the men were allowed to maintain their claims of innocence in the case and were set free.

The case -- and the question of their guilt or innocence -- had become a cause celebre, attracting attention from actor Johnny Depp, Pearl Jam singer Eddie Vedder and Dixie Chick Natalie Maines, among others.

It is also the subject of 1996 Emmy-winning documentary "Paradise Lost: The Child Murders at Robin Hood Hills" by directors Joe Berlinger and Bruce Sinofsky that aired on HBO.

The directors subsequently made two followups, "Paradise Lost 2: Revelations" in 2000, and "Paradise Lost 3: Purgatory," which will screen at September's Toronto International Film Festival and air on HBO this coming January. HBO said it will re-work the ending of the third movie due to Friday's decsion.

"To see our work culminate in the righting of this tragic miscarriage of justice is more than a filmmaker could ask for," Berlinger said in a statement after attending Friday's court hearing with Sinofsky.

The third movie "tells the entire story, from the arrests in 1993 to the growing movement, through the entire appeals process and the uncovering of new evidence, concluding with their release," the directors and HBO said.

Pressure has been mounting in recent years to free the men who were convicted of murdering 8-year-old Cub Scouts Steven Branch, Christopher Byers and James Michael Moore.

Police at the time called the murders "satanic" because the children's naked bodies had been bound and mutilated.

Of the West Memphis Three, who were teenagers at the time of the murders, Baldwin and Misskelley were sentenced to life in prison, and Echols was on death row.

Yet, they had always maintained their innocence. Recent DNA tests did not link the men to the crime scene and, in fact, showed the presence of others who have never been identified.

Arkansas officials said they believed the defendants might be acquitted in a new trial due to the deaths of witnesses, DNA tests, changing stories, and stale evidence.

(Editing by Jill Serjeant)

Source: http://us.rd.yahoo.com/dailynews/rss/tv/*http%3A//news.yahoo.com/s/nm/20110819/tv_nm/us_hbo_westmemphis3

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Computational method predicts new uses for existing medicines; Match-making program uses gene expression patterns

ScienceDaily (Aug. 18, 2011) ? For the first time ever, scientists are using computers and genomic information to predict new uses for existing medicines.

A National Institutes of Health-funded computational study analyzed genomic and drug data to predict new uses for medicines that are already on the market. A team led by Atul J. Butte, M.D., Ph.D., of Stanford University, Palo Alto, Calif., reports its results in two articles in the Aug. 17 online issue of Science Translational Medicine.

"Bringing a new drug to market typically takes about $1 billion, and many years of research and development," said Rochelle M. Long, Ph.D., who directs the NIH Pharmacogenomics Research Network. "If we can find ways to repurpose drugs that are already approved, we could improve treatments and save both time and money."

The scientists drew their data from the NIH National Center for Biotechnology Information Gene Expression Omnibus, a publicly available database that contains the results of thousands of genomic studies on a wide range of topics, submitted by researchers across the globe. The resource catalogs changes in gene activity under various conditions, such as in diseased tissues or in response to medications.

Butte's group focused on 100 diseases and 164 drugs. They created a computer program to search through the thousands of possible drug-disease combinations to find drugs and diseases whose gene expression patterns essentially cancelled each other out. For example, if a disease increased the activity of certain genes, the program tried to match it with one or more drugs that decreased the activity of those genes.

Many of the drug-disease matches were known, and are already in clinical use, supporting the validity of the approach. For example, the analysis correctly predicted that prednisolone could treat Crohn's disease, a condition for which it is a standard therapy.

Other matches were surprises. Butte's team chose to further investigate two such drug-disease combinations: an anti-ulcer medicine (cimetidine) that matched with lung cancer, and an anticonvulsant (topiramate) that matched with inflammatory bowel disease, which includes Crohn's disease.

To confirm the cimetidine-lung cancer link, the team tested cimetidine on human lung cancer cells in lab dishes and implanted in mice. In both cases, the drug slowed the growth of the cancer cells compared to the control group (cells or mice) that had not received cimetidine.

To test whether the anticonvulsant topiramate had an effect on inflammatory bowel diseases, the researchers administered the drug to rats that had bowel disease symptoms -- diarrhea and inflammation, ulcers and microscopic damage in the colon. The drug decreased all of these symptoms, sometimes even better than prednisolone.

The work also has more fundamental value. The scientists noticed that diseases with similar molecular processes (for example, those that affect the immune system) clustered together in the analysis. So did drugs with similar effects (for example, those that slow cell division). The researchers believe that, by studying unexpected members of these clusters, they could learn more about how certain diseases progress and how some drugs work at the molecular level.

"This work is still at an early stage, but it is a promising proof of principle for a creative, fast and affordable approach to discovering new uses for drugs we already have in our therapeutic arsenal," Long said.

This research was supported by three NIH components: the National Institute of General Medical Sciences (R01GM079719), the National Cancer Institute (R01CA138256) and the National Library of Medicine (T15LM007033).

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by NIH/National Institute of General Medical Sciences.

Journal References:

  1. Joel T. Dudley, Marina Sirota, Mohan Shenoy, Reetesh K. Pai, Silke Roedder, Annie P. Chiang, Alex A. Morgan, Minnie M. Sarwal, Pankaj Jay Pasricha, Atul J. Butte. Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease. Science Translational Medicine, 2011; 3 (96): 96ra76 DOI: 10.1126/scitranslmed.3002648
  2. Marina Sirota, Joel T. Dudley, Jeewon Kim, Annie P. Chiang, Alex A. Morgan, Alejandro Sweet-Cordero, Julien Sage, Atul J. Butte. Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data. Science Translational Medicine, 2011; 3 (96): 96ra77 DOI: 10.1126/scitranslmed.3001318

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Source: http://www.sciencedaily.com/releases/2011/08/110817142845.htm

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