Thursday, November 10, 2011

Paterno, president out in Penn State abuse scandal (Reuters)

STATE COLLEGE, Pennsylvania (Reuters) ? Famed U.S. college football coach Joe Paterno and the president of Penn State University were fired on Wednesday in fallout from a child-abuse scandal and cover-up involving a former assistant coach and school officials.

The move by the university's board of trustees thwarted an attempt by Paterno, 84 and one of the most iconic names in American sports, to leave the team on his own terms. It triggered largely peaceful protests on campus from students.

"I am disappointed with the Board of Trustees' decision, but I have to accept it," Paterno said in a statement.

"I am grateful beyond words to all of the coaches, players and staff who have been a part of this program. And to all of our fans and supporters, my family and I will be forever in your debt."

During his 46 years as head coach, Paterno won two national championships, more games than any other and the adoration of Penn State's students, alumni and staff.

Paterno said earlier on Wednesday he would step down at the end of this season, a few weeks from now, and suggested the trustees should not worry about his status.

But the trustees said they needed to make immediate changes "in the best interests of the university" given the grave issues now facing it.

"Effective immediately, Doctor (Graham) Spanier is no longer president of the university," John Surma, vice chairman of trustees, told a news conference. "Joe Paterno is no longer the head football coach, effective immediately."

STUNNED GASP

Spanier had been president of Penn State for 16 years. His departure had been widely rumored on Wednesday. The announcement about Paterno triggered a stunned gasp from those at the press conference.

Tom Bradley, currently the defensive coordinator, will take over as interim head coach, starting with Saturday's final home game of the season against the University of Nebraska.

The trustees spent several hours on Wednesday evening deciding how to handle the unprecedented crisis that has engulfed the prestigious university in central Pennsylvania.

"These decisions were made after careful deliberations," said Surma. "We don't yet know all the facts and there are many details that are yet to be worked out."

Penn State, its football program and Paterno were thrown into turmoil on Saturday when charges were filed against long-time assistant coach Jerry Sandusky.

Sandusky, 67, is accused of sexually abusing at least eight boys over more than a decade. Two other university officials have been charged with not reporting an incident in 2002 when Sandusky allegedly was seen sexually assaulting a child.

Lawyers for all three men have said they deny the charges and maintain their innocence.

The situation was a tragedy and "one of the great sorrows of my life," Paterno said in his statement earlier.

"With the benefit of hindsight, I wish I had done more," Paterno said of his actions after learning of the allegations about Sandusky in 2002.

Spanier, who was criticized for not speaking out earlier, was contrite.

"There is wisdom in a transition in leadership so that there are no distractions in allowing the university to move forward," he said in a statement.

"I was stunned and outraged to learn that any predatory act might have occurred in a university facility or by someone associated with the university."

The board named Dr. Rodney Erickson, executive vice president and provost, as the university's interim president.

COVER-UP?

Earlier, the U.S. Department of Education said it would launch an investigation into the conduct at Penn State, which must disclose criminal offenses committed on campus each year.

"If these allegations of sexual abuse are true then this is a horrible tragedy for those young boys," Education Secretary Arne Duncan said in a statement. "If it turns out that some people at the school knew of the abuse and did nothing or covered it up, that makes it even worse."

The charges against Sandusky, who was new head coach Bradley's predecessor as defensive coordinator, and accusations school officials covered up the abuse for years have shaken the university.

A local artist painted over the image of Sandusky sitting next to Paterno on the "Inspiration" mural he created on campus in 2001 to honor people he admired. Michael Pilato, who said he got hundreds of emails asking him to remove Sandusky, left an empty chair and a blue ribbon to honor the alleged victims.

Sandusky allegedly recruited his victims from "The Second Mile," a charity he founded to help troubled children, and subjected them to a pattern of escalating abuse. A preliminary hearing originally set for Wednesday was postponed to December 7.

Former athletic director Tim Curley and former finance official Gary Schultz were charged on Monday with failing to alert police after they were told Sandusky was seen sodomizing a young boy in the locker room showers in 2002. They were also charged with perjury in their statements to a grand jury. All three men, through their lawyers, have denied the charges and maintained their innocence.

EMOTIONAL END

Paterno held a short meeting with coaching staff and players on Wednesday, which participants described as tearful and highly emotional.

The coach, with his thick, black-rimmed glasses and navy windbreaker, has been the face of Penn State football for generations.

Paterno's firing and Bradley's appointment sets up high drama on Saturday, when Penn State will take an 8-1 record into its final home game of the year against the University of Nebraska.

Under Paterno, Penn State won 409 games, a record for a coach in major college football. He set the record when the Nittany Lions beat the University of Illinois on October 29, just days before Sandusky was charged on November 5.

The scandal has rocked the sprawling campus of about 45,000 students in State College in central Pennsylvania, the flagship of about two dozen Penn State campuses across the state.

Hundreds of emotional, chanting, but mostly peaceful students converged on the university administration building late on Wednesday to protest the firing of Paterno.

The firing also stunned "Paternoville," the tent city that sprouts outside the football stadium before every home game, when students camp out to be first in line for good seats.

"Everything is calm at Beaver Stadium -- just a lot of emotions. We do not agree with any irrational decisions made downtown. Safe up here," said a Paternoville tweet.

College football is hugely popular in the United States, drawing massive television audiences every Saturday in the late summer and fall and filling huge stadiums. Beaver Stadium, which seats about 106,000, is one of the largest.

Teams generate million of dollars in revenue and successful ones raise the profile of their universities. That, in turn, helps fundraising -- such as the $2 billion capital campaign now under way at Penn State.

University trustees voted on Tuesday to name a special committee to determine any failures over Sandusky's alleged crimes and officials' response, saying they were "outraged by the horrifying details contained in the grand jury report."

That report detailed alleged sexual assaults by Sandusky over 15 years -- during his time as a Penn State coach and after his retirement in 1999.

A ninth potential victim, now in his 20s, has since come forward and Pennsylvania police have set up a hotline to call.

(Reporting by Ian Simpson in State College, Mark Shade in Harrisburg and Dave Warner in Philadelphia; Writing by Ros Krasny; Editing by John O'Callaghan and Eric Walsh)

Source: http://us.rd.yahoo.com/dailynews/rss/crime/*http%3A//news.yahoo.com/s/nm/20111110/us_nm/us_usa_crime_coach_paterno

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Tuesday, November 8, 2011

No resolution on Greek power-sharing talks (AP)

ATHENS, Greece ? Critical power-sharing talks between Greece's two main parties dragged into Wednesday without any signs of progress on who will head a new interim government, despite intense European pressure to end the political crisis that has put the euro under threat.

Negotiations between Prime Minister George Papandreou and opposition leader Antonis Samaras began Monday. The two reached a landmark weekend agreement to forge an interim government that will shepherd the country's new euro130 billion ($179 billion) European rescue package through Parliament and end an intense political crisis that threatened Greece's solvency and membership of the euro.

Officials on both the governing Socialists' side and the opposition conservatives said there was broad agreement on naming former European Central Bank vice president Lucas Papademos as premier to take over from Papandreou. The officials spoke on condition of anonymity because they were not authorized to discuss the developing situation.

Papandreou said in the early afternoon that a deal was close.

But as the evening wore on, several government and opposition officials said a main sticking point arose after European officials demanded written guarantees by both main parties that they supported the new debt deal ? a demand with which the opposition conservatives took issue. They also spoke on condition of anonymity, citing the same reason.

However, a conservative party official said the issue causing a delay was related to who would be finance minister in the new government.

That official and a government official said Greece's representative to the International Monetary Fund, Panagiotis Roumeliotis, was a contender to take over from Evangelos Venizelos in the post. They both spoke on condition of anonymity because they were not authorized to discuss the private negotiations.

Opposition conservative party spokesman Yiannis Michelakis indicated that the sticking point was with the governing Socialists, saying that any signs of progress would come from the prime minister's office rather than opposition party headquarters.

But there were clear signs of irritation from the conservatives over European demands for guarantees from Athens.

On Monday, eurozone finance ministers said the heads of the two main parties had to commit in writing to the terms of the country's bailouts before Athens can receive a vital euro8 billion ($11 billion) loan installment without which the country faces default within weeks.

"It is indeed essential that a new government will express its explicit and unequivocal commitment in writing concerning all the decisions taken by the 17 euro area member states on Oct. 27," EU economic affairs commissioner Olli Rehn said in Brussels Tuesday.

The next rescue loan installment "can then be disbursed once there is full clarity about Greece sticking to the agreed course and policies," Rehn said. "It should be clear in Athens that solidarity is a two-way street and we expect a united political class to carry out its part of responsibilities."

Michelakis reacted with irritation.

"The fact that Europe has lost any trace of trust in the (Socialist) government does not mean it can insult our national dignity," he said in a statement in response to Rehn's statement.

Earlier in the day, a senior Greek government official said Greece's eurozone partners had demanded even more during their meeting in Brussels on Monday ? that Papandreou and Samaras, the Bank of Greece governor, the new prime minister and the new finance minister all co-sign a letter reaffirming their commitment to the country's bailout deals and economic reforms.

Samaras appeared to take offense.

"There is national dignity," he said in a statement. "I have long and repeatedly explained why, in order to protect the Greek economy and the euro, the implementation of the (new European debt deal) has become 'inevitable'. I do not allow anyone to cast doubt on these statements."

Without the Oct. 27 deal, which took European leaders months to work out, Greece would go bankrupt, potentially wrecking Europe's banking system and sending the global economy back into recession.

"I believe that we are now close to an agreement," Papandreou said during a Cabinet meeting Tuesday afternoon.

"When one cooperates with another party, there are some red lines on either side which of course restrict things," he said. "Therefore, while one could imagine ideal situations, in reality these do not exist, and one seeks simply to find the best possible solution."

Papandreou's ministers offered him their resignations during the Cabinet meeting to pave the way for the creation of the interim government, which is to last until an early election expected Feb. 19.

The political crisis erupted last week, when Papandreou said he would put the new European rescue package to a referendum. Other eurozone nations were horrified by the delay, markets around the world tanked and Greece's international creditors froze the payment of the next bailout.

Papandreou withdrew the plan Thursday after Samaras indicated he would back the new deal. They then agreed Sunday for Papandreou to step down and the temporary government to be formed.

Greece has survived since May 2010 on a euro110 billion ($150 billion) rescue-loan program from its eurozone partners and the International Monetary Fund, but all agree it's not enough. A second rescue package has been created that involves private bondholders voluntarily agreeing to cancel 50 percent of their Greek debt.

In return for its bailout cash, Greece has endured 20 months of punishing austerity measures. The efforts by Papandreou's government to keep the country solvent have prompted violent protests, crippling strikes and a sharp decline in living standards for most Greeks. ____

Kantouris contributed from Thessaloniki. Associated Press writers Nicholas Paphitis and Derek Gatopoulos in Athens, and Gabriele Steinhauser in Brussels contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/ap/20111108/ap_on_bi_ge/eu_greece_financial_crisis

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Barnes & Noble's Nook Tablet gets real, we go hands-on (video)

Sure, we can't say we didn't see this coming -- Barnes & Noble today launched its answer to the Kindle Fire. The new Nook Tablet certainly isn't all that new from an aesthetic standpoint, compared with the Nook Color. Walking into a store blind, it would be awfully tough to distinguish the devices -- though the Tablet is bit lighter, color-wise. It's also lighter in terms of actual weight, shedding an ounce from its predecessor -- a fact that's really only noticeable when holding both devices in your hand.

The Nook Color certainly did well for the company, becoming a top seller the previous holiday season, and Barns & Noble clearly took an "if it ain't broke" approach here... It really is a nice form factor, easy to hold in a single hand for reading and watching video. The company also promises that a case with a built-in stand is coming, so you can take full advantage of that wide screen when watching longer videos on Netflix or Hulu Plus. The Power button is located in the top left and corner, with volume on the right. The microSD slot can be found just behind the Tablet's distinctive metal bar. What separates Barnes & Noble's two higher end readers is largely internal. Unfortunately, the products being shown off at today's event weren't quite ready for prime time.

We managed to see a bit of video demoed on the thing, and certainly the screen looked quite nice as it played back the trailer for J Edgar and flipped through the pages of a Spider-Man comic. Unfortunately, we're going to have to spend a bit more time with a final version of the product before we feel comfortable recommending the Tablet, given its $50 premium over both the Nook Color and the Kindle Fire. Check out a hands-on video with the device after the break.

Continue reading Barnes & Noble's Nook Tablet gets real, we go hands-on (video)

Barnes & Noble's Nook Tablet gets real, we go hands-on (video) originally appeared on Engadget on Mon, 07 Nov 2011 11:43:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/11/07/barnes-and-nobles-nook-tablet-gets-real-we-go-hands-on-video/

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Saturday, November 5, 2011

BIO101 - Introduction to Anatomy and Physiology

In this lecture, as well as in the previous one and the next one, I tackle areas of Biology where I am really weak: origin of life, diversity of life, and taxonomy/systematics. These are also areas where there has been a lot of change recently (often not yet incorporated into textbooks), and I am unlikely to be up-to-date, so please help me bring these lectures up to standards?. This post was originally written in 2006 and re-posted a few times, including in 2010.

As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it ? from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics ? from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.

Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.

I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros ? discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don?t push just your own preferred hypothesis if a question is not yet settled ? give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language ? edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let?s discuss the overall syllabus ? is there a better way to organize all this material for such a fast-paced class.

???????????????

Anatomy is the sub-discipline of biology that studies the structure of the body. It describes (and labels in Latin) the morphology of the body: shape, size, color and position of various body parts, with particular attention to the internal organs, as visible by the naked eye. Histology is a subset of anatomy that describes what can be seen only under the microscope: how cells are organized into tissues and tissues into organs. (Classical) embryology describes the way tissues and organs change their shape, size, color and position during development.

Anatomy provides the map and the tools for the study of the function of organs in the body. It describes (but does not explain) the structure of the body. Physiology further describes how the body functions, while evolutionary biology provides the explanation of the structure and the function.

While details of human anatomy are essential in the education of physicians and nurses (and animal anatomy for veterinarians), we do not have time, nor do we need to pay too much attention to fine anatomical detail. We will pick up on relevant anatomy as we discuss the function of organs: physiology.

There are traditionally two ways to study (and teach) physiology. The first approach is medical/biochemical. The body is subdivided into organ systems (e.g., respiratory, digestive, circulatory, etc.) and each system is studied separately, starting with the physiology of the whole organism and gradually going down to the level of organs, tissues, cells and molecules, ending with the biochemistry of the physiological function. Only the human body is studied. Often, pathologies and disorders are used to illustrate how organs work ? just like fixing a car engine by replacing a broken part helps us understand how the engine normally works, so studying diseases helps us understand how the healthy human body works.

The other approach is ecological/energetic. The physiological functions are divided not by organ system, but by the problem ? imposed by the environment ? that the body needs to solve in order to survive and reproduce, e.g., the problem of thermoregulation (body temperature), osmoregulation (salt/water balance), locomotion (movement), stress response, etc., each problem utilizing multiple organ systems. Important aspect of this approach is the study of the way the body utilizes energy: is the solution energetically optimal? Individuals that have solved a problem with a more energy-efficient physiological mechanism will be favored by natural selection ? thus this approach is also deeply rooted in an evolutionary context. Finally, this approach is very comparative ? study of animals that live in particularly unusual or harsh environments helps us understand the origin and evolution of physiological mechanisms both in humans and in other animals.

The textbook is unusually good (for an Introductory Biology textbook) in trying to bridge and combine both approaches. Unfortunately, we do not have enough time to cover all of the systems and all of the problems in detail, so we will stick to the first, medical approach and cover just a few of the systems of the human body, but I urge you to read the relevant textbook chapters in order to understand the ecological and evolutionary aspects of physiology as well (not to mention some really cool examples of problem-solving by animal bodies). Hint: use the ?Self Test? questions at the end of each chapter and if you answer them correctly, you are ready for the exam.

Let?s start out by looking at a couple of important basic principles that pertain to all of physiology. One such principle is that of scaling, for which you should read the handout that we will discuss in class next time. The second important principle in physiology is the phenomenon of feedback loops: both negative and positive feedback loops.

Negative feedback loop works in a way very similar to the graph we drew when we discussed behavior. The body has a Sensor that monitors the state of the body ? the internal environment (as opposed to external environment we talked about when discussing behavior), e.g,. the blood levels of oxygen and carbon dioxide, blood pressure, tension in the muscles, etc. If something in the internal environment changes from the normal, optimal values, the sensor informs the Integrator (usually the nervous system) which initiates action (via an Effector) to bring back the body back to its normal state.

Thus, an event A leads to response B which leads to the countering and elimination of the event A. Almost every function in the body operates like a negative feedback loop. For instance, if a hormone is secreted, along with the functional effect of that hormone, there will also be a trigger of a negative feedback loop that will stop the further secretion of that hormone.

There are very few functions in the body that follow a different pattern ? the positive feedback loop. There, an event A leads to response B which leads to re-initiation and intensification of the event A which leads to a stronger response B?and so on, until a threshold is reached or the final goal is accomplished, when everything goes abruptly back to normal.

We will take a look at an example of the positive feedback loop that happens in the nervous system next week. For now, let?s list some other notable positive feedback loops in humans.

First, the blood clotting mechanism is a cascade of biochemical reactions that operates according to this principle. An injury stimulates production of a molecule that triggers production of another molecule which triggers production of another molecule as well as production of more of the first molecule, and so on, until the injury has completely closed.

Childbirth is another example of the positive feedback loop. When the baby is ready to go out (and there?s no stopping it at this point!), it releases a hormone that triggers the first contraction of the uterus. The contraction of the uterus pushes the baby out a little. That movement of the baby stretches the wall of the uterus. The wall of the uterus contains stretch receptors which send signals to the brain. In response to the signal, the brain (actually the posterior portion of the pituitary gland, which is an outgrowth of the brain) releases hormone oxytocin. Oxytocin gets into the bloodstream and reaches the uterus triggering the next contraction which, in turn, moves the baby which further stretches the wall of the uterus, which results in more release of oxytocin?and so on, until the baby is expelled, when everything returns to normal.

Next example of the positive feedback loop is also related to babies ? nursing. When the infant is hungry, mother brings its mouth to the nipple of the breast. When the baby latches onto the nipple and tries to suck, this stimulates the receptors in the nipple which notify the brain. The brain releases hormone oxytocin from the posterior pituitary gland. Oxytocin gets into the bloodstream and stimulates the mammary gland to release milk (not to synthesize milk ? it is already stored in the breasts). Release of milk at the nipple stimulates the baby to start suckling vigorously, which stimulates the receptors in the nipple even more, so there is even more oxytocin released from the pituitary and even more milk is released by the mammary gland, and so on, until the baby is satiated and unlatches from the breast, when everything goes back to normal.

Next example of the positive feedback loop is also related to babies, but nine months earlier. Copulation ? yes, having sex ? is an example of a positive feedback loop, both in females and in males. Initial stimulation of the genitals stimulates the touch receptors which notify the brain which, in turn, stimulates continuation (and gradual speeding up) of movement, which provides further tactile stimulation, and so on, until the orgasm, after which everything goes back to normal (afterglow notwithstanding).

The last example also applies to the nether regions of the body. Micturition (urination) is also a positive feedback loop. The wall of the urinary bladder is built in such a way that there are several layers of cells. As the bladder fills up, the wall stretches and these cells move around until the wall is only a single cell thick. At this point, urination is inevitable (cannot be stopped by voluntary control). Beginning of the urination starts the movement of the cells back from single-layer state to multi-layer state. This contracts the bladder further which forces urine out even more which contracts the wall of the bladder even more, and so on until the bladder is completely empty again and everything goes back to normal.

The concept of feedback loops is essential for the understanding of the principle of homeostasis. Homeostatic mechanisms ensure that the internal environment remains constant and all the parameters are kept at their optimal levels (e.g,. temperature, pH, salt/water balance, etc) over time. If a change in the environment (e.g., exposure to heat or cold) results in the change of internal body temperature, this is sensed by thermoreceptors in the body. This triggers corrective mechanisms: if the body is overheated, the capillaries in the skin expand and radiate heat and the sweat gland release sweat; if the body is too cold, the capillaries in the skin contract, the muscles start shivering, the hairs stand up (goosebumps), and the thyroid hormones are released, resulting in opening of pores in the membranes of mitochondria in the muscles, thus reducing the efficiency of the break-down of glucose to water and carbon-dioxide, thus producing excess heat. Either way, the body temperature will be returned to its optimal level (around 37 degrees Celsius), which is called the set-point for body temperature. Each aspect of the internal environment has its own set-point which is defended by homeostatic mechanisms.

While essentially correct, there is a problem with the concept of homeostasis. One of the problems with the term ?homeostasis? is linguistic: the very term homeostasis is misleading. ?Homeo? means ?similar, same? and ?stasis? means ?stability?. Thus, the word homeostasis (coined by Walter Cannon in the early 20th century) suggests strong and absolute constancy. Imagine that you were told to draw a graphical representation of the concept of homeostasis in 10 seconds. Without sufficient time to think, you would probably draw something like this:

The main characteristic of this graph is that the set-point is constant over time. But that is not how it works in the real world. The graph above is correct only if the time-scale (on the X-axis) spans only seconds to minutes. If it is expanded to hours, days or years, the graph would be erroneous ? the line would not be straight and horizontal any more. The set point changes in a predictable and well-controlled manner. For instance, the set-point for testosterone levels in the blood in human males over the course of a lifetime may look like this:

That would be an example of developmental control of a set-point. At each point in time, that set-point is defended by homeostatic mechanisms, but the set-point value is itself controlled by other physiological processes. Another example of controlled change of a set-point may look like this:

This would be an example of an oscillatory control of a set-point. In the early 1980s, Nicholas Mrosovsky coined a new term to replace ?homeostasis? and specifically to denote controlled changes in set-points of all biochemical, physiological and behavioral values ? rheostasis.

Almost every aspect of physiology (and behavior) exhibits rheostasis, both developmental and oscillatory (daily and/or yearly rhythms). Some notable exceptions are blood pH (which has to be kept within very narrow range 7.35-7.45) and blood levels of Calcium. If pH or Calcium levels move too far away from the optimal value, cells in the body (most notably nerve cells, muscles and heart cells) cannot function properly and the body is in danger of immediate death.

Additional Readings:

?Medicine Needs Evolution? by Nesse, Stearns and Omenn

Previously in this series:

BIO101 ? Biology and the Scientific Method
BIO101 ? Cell Structure
BIO101 ? Protein Synthesis: Transcription and Translation
BIO101: Cell-Cell Interactions
BIO101 ? From One Cell To Two: Cell Division and DNA Replication
BIO101 ? From Two Cells To Many: Cell Differentiation and Embryonic Development
BIO101 ? From Genes To Traits: How Genotype Affects Phenotype
BIO101 ? From Genes To Species: A Primer on Evolution
BIO101 ? What Creatures Do: Animal Behavior
BIO101 ? Organisms In Time and Space: Ecology
BIO101 ? Origin of Biological Diversity
BIO101 ? Evolution of Biological Diversity
BIO101 ? Current Biological Diversity

Source: http://rss.sciam.com/click.phdo?i=7af2d1d0c9f6626b502547ff4b5caebf

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Friday, November 4, 2011

Amtrak prepares for Thanksgiving travel rush

Amtrak is preparing for Thanksgiving, the rail service's busiest travel period of the year, with extra trains and rail cars added to routes through Chicago, the Midwest and other regions.

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    5. Expect fewer fliers, packed planes for Thanksgiving

The two busiest travel days are expected to be the Wednesday before Thanksgiving, Nov. 23, and the Sunday after, Nov. 27.

Amtrak saw record ridership last year with more than 700,000 passengers during Thanksgiving week.

Amtrak advises customers to purchase tickets early to avoid the rush and arrive at the station early on the day of travel.

There's a limit of two carry-on bags per person on Amtrak trains. Passengers should make sure luggage is tagged with a name and address. And passengers should carry a valid photo ID at all times; it may be requested aboard trains.

Expect fewer fliers, packed planes for Thanksgiving

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45152967/ns/travel-news/

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Low vitamin D levels do not increase the risk of chronic obstructive pulmonary disease

Low vitamin D levels do not increase the risk of chronic obstructive pulmonary disease [ Back to EurekAlert! ] Public release date: 4-Nov-2011
[ | E-mail | Share Share ]

Contact: Nathanial Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society

Vitamin D levels are not related to acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in patients with severe COPD, according to a large prospective cohort study involving 973 North American patients. The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the study, a secondary analysis of data from a randomized, controlled trial of the effects of azithromycin on the frequency of AECOPD, no relationship was found between baseline Vitamin D levels and time to first AECOPD or between vitamin D levels and AECOPD exacerbation rates.

"Vitamin D insufficiency and deficiency are common in patients with COPD, and patients with severe COPD are at the highest risk for exacerbations, so we hypothesized that low vitamin D levels might increase the risk of AECOPDs," said Ken M. Kunisaki, M.D., of the Minneapolis Veterans Affairs Medical Center. "Our negative results are in contrast with earlier studies in which lower vitamin D levels were associated withhigher rates of respiratory infections in adults and more frequent asthma exacerbations in children."

In the current study, mean forced expiratory volume in one second (FEV1) was 1.12L, 40% of predicted. Mean vitamin D level at baseline was 25.7 12.8 ng/mL, with 33.1% of subjects categorized as vitamin D insufficient (?20 ng/mLbut

During 1 year of follow-up, study subjects experienced a total of 1415 AECOPDs. Of 973 patients,360 (37%)remained AECOPD-free, 278 (29%) had 1 AECOPD, 133 (14%)had 2 AECOPDs, and 202 (21%) had 3 or moreAECOPDs.

In the primary analysis, vitamin D levels had no relationship to time to first AECOPD; for a 10 ng/mL increment in vitamin D level, the estimated hazard ratio was 1.04 (95% confidence interval: 0.97-1.12). In secondary analyses, vitamin D levels were not related to annualized rates of AECOPDs in either Poisson (p=0.82)or negative binomial analyses (p=0.87).

Patients with severe vitamin D deficiency had a higher mean rateof AECOPDs, but this difference was not statistically significant. Patients with severe vitamin D deficiency did not exhibit faster time to first AECOPD than other patients.

The study had some limitations. Vitamin D levels were only assessed at baseline, and so may have changed during the study period. Seasonal changes in vitamin D levels may also have occurred.

"Contrary to what we expected, baseline vitamin D levelswere not related to the risk of subsequent AECOPDs in this large group of COPD patients at high risk of AECOPD," Dr. Kunisaki said. "Vitamin D supplementation is unlikely to have an effect on AECOPD risk in these patients."

###

About the American Journal of Respiratory Research and Critical Care Medicine:

With an impact factor of 10.191, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields. Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.



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Low vitamin D levels do not increase the risk of chronic obstructive pulmonary disease [ Back to EurekAlert! ] Public release date: 4-Nov-2011
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Contact: Nathanial Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society

Vitamin D levels are not related to acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in patients with severe COPD, according to a large prospective cohort study involving 973 North American patients. The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the study, a secondary analysis of data from a randomized, controlled trial of the effects of azithromycin on the frequency of AECOPD, no relationship was found between baseline Vitamin D levels and time to first AECOPD or between vitamin D levels and AECOPD exacerbation rates.

"Vitamin D insufficiency and deficiency are common in patients with COPD, and patients with severe COPD are at the highest risk for exacerbations, so we hypothesized that low vitamin D levels might increase the risk of AECOPDs," said Ken M. Kunisaki, M.D., of the Minneapolis Veterans Affairs Medical Center. "Our negative results are in contrast with earlier studies in which lower vitamin D levels were associated withhigher rates of respiratory infections in adults and more frequent asthma exacerbations in children."

In the current study, mean forced expiratory volume in one second (FEV1) was 1.12L, 40% of predicted. Mean vitamin D level at baseline was 25.7 12.8 ng/mL, with 33.1% of subjects categorized as vitamin D insufficient (?20 ng/mLbut

During 1 year of follow-up, study subjects experienced a total of 1415 AECOPDs. Of 973 patients,360 (37%)remained AECOPD-free, 278 (29%) had 1 AECOPD, 133 (14%)had 2 AECOPDs, and 202 (21%) had 3 or moreAECOPDs.

In the primary analysis, vitamin D levels had no relationship to time to first AECOPD; for a 10 ng/mL increment in vitamin D level, the estimated hazard ratio was 1.04 (95% confidence interval: 0.97-1.12). In secondary analyses, vitamin D levels were not related to annualized rates of AECOPDs in either Poisson (p=0.82)or negative binomial analyses (p=0.87).

Patients with severe vitamin D deficiency had a higher mean rateof AECOPDs, but this difference was not statistically significant. Patients with severe vitamin D deficiency did not exhibit faster time to first AECOPD than other patients.

The study had some limitations. Vitamin D levels were only assessed at baseline, and so may have changed during the study period. Seasonal changes in vitamin D levels may also have occurred.

"Contrary to what we expected, baseline vitamin D levelswere not related to the risk of subsequent AECOPDs in this large group of COPD patients at high risk of AECOPD," Dr. Kunisaki said. "Vitamin D supplementation is unlikely to have an effect on AECOPD risk in these patients."

###

About the American Journal of Respiratory Research and Critical Care Medicine:

With an impact factor of 10.191, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields. Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-11/ats-lvd110111.php

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Wednesday, November 2, 2011

Army Lt. Chad Ware Wins 2011 Marine Corps Marathon (VIDEO)

WASHINGTON -- A day after a freak October snowstorm pushed through the D.C. region, more than 30,000 runners participated in Sunday's Marine Corps Marathon, which wound its way between Arlington County and the District of Columbia on a 26.2 mile route.

As Stars and Stripes reported, "[s]ome looked like they were dressed more for skiing than running. The previous day's pre-winter storm also turned anything that was not paved into a mud-caked quagmire."

Army Lt. Chad Ware, 27, who has been battling stomach problems, placed first with an official time of 2 hours, 19 minutes and 16 seconds, which The Washington Post noted was a "personal-best by nearly 90 seconds and the race's best time in 14 years."

Tezata Dengersa, a 30-year-old from Turkey, won the women's division with an unofficial finish in 2 hours, 45 minutes and 28 seconds.

While the majority of the route was relatively flat, runners faced uphill climbs on Lee Highway in Arlington through the second mile and again on Reservoir Road in the Palisades into the seventh mile.

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Source: http://www.huffingtonpost.com/2011/10/30/marine-corps-marathon-201_n_1066575.html

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Testimony ends in Michael Jackson doctor trial (AP)

LOS ANGELES ? Michael Jackson's doctor told a judge Tuesday that he would not testify in his own defense, as testimony came to a close in the involuntary manslaughter trial.

Closing arguments in the six-week case will begin Thursday ? one of the final steps before jurors begin deliberations.

Dr. Conrad Murray held his hands over his mouth as if he was praying in the moments before Superior Court Judge Michael Pastor asked the cardiologist whether he intended to take the stand.

The judge also asked if he understood the decision was his alone to make.

"Have you made up your mind," Pastor asked.

Murray paused, looked at all his lawyers, seemed to sigh and said, "My decision is I will not testify in this matter."

The judge asked lead attorney Ed Chernoff if he had conferred with Murray about his rights and Chernoff said yes.

"The court finds the defendant has knowingly, freely and explicitly waived his right to testify," the judge said. "I certainly will respect that decision."

Murray had left open the possibility of testifying on Monday, when he told the judge that he had not made a final decision.

Murray's announcement Tuesday was made outside the presence of jurors.

Defense attorneys rested their case after calling 16 witnesses. A total of 49 witnesses testified over 22 days of trial.

Prosecutors contend Murray gave Jackson a fatal dose of the anesthetic propofol in the bedroom of the singer's mansion. Defense attorneys claim Jackson self-administered the dose when Murray left the room.

The last witness was prosecution propofol expert, Dr. Steven Shafer, who was called by prosecutors as a rebuttal witness to address a few points raised by previous testimony.

Murray has pleaded not guilty to involuntary manslaughter in Jackson's death on June 25, 2009. He could face up to four years behind bars and the loss of his medical license if convicted.

Murray's decision against testifying came after hours of intense grilling by a prosecutor of Dr. Paul White, an anesthesia expert who has said he believes Jackson injected himself with the fatal dose of propofol when Murray left his bedside.

After asking only eight questions on Monday, Deputy District Attorney David Walgren had gotten White to acknowledge that Murray had repeatedly violated the physician's standard of care.

Throughout the day, White also told jurors that he would have never done what Murray was doing ? giving Jackson propofol as a sleep aid.

___

AP Entertainment Writer Anthony McCartney contributed to this report.

___

McCartney can be reached at http://twitter.com/mccartneyAP

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/ap/20111101/ap_en_mu/us_michael_jackson_doctor

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Tuesday, November 1, 2011

Qantas flights back to normal after grounding (AP)

SYDNEY ? Qantas Airways said its flights were back on schedule Tuesday, a day after an Australian court ruling ended 48 hours of travel chaos stemming from the airline's decision to ground its entire fleet.

Qantas, the world's 10th-largest airline, said all flights were operating on time and as scheduled, with the remaining backlog of passengers affected by the two-day grounding expected to be cleared by Tuesday afternoon.

The airline grounded its fleet Saturday in response to months of strikes by unions representing pilots, aircraft mechanics, baggage handlers and caterers. The move threw the travel plans of tens of thousands of passengers into disarray, and prompted the government to order an emergency court hearing.

On Monday, an arbitration court ordered an end to the strikes, which had forced the cancellation of 600 flights in recent months, disrupted travel for 70,000 customers and cost Qantas 70 million Australian dollars ($75 million). The court also canceled a staff lockout, and the airline began flying again about 12 hours later.

The court gave the airline and unions 21 days to reach an agreement. If no deal is reached by then, they will be forced into mandatory arbitration.

"The question is whether the parties can now act in a mature way," Transport Minister Anthony Albanese told reporters Tuesday in Australia's capital, Canberra. "We've called upon both Qantas and the unions to get down to business and to get this deal done."

Qantas enraged union workers in August when it said it would improve its loss-making overseas business by creating an Asia-based airline with its own name and brand. The five-year restructure plan will cost 1,000 jobs.

The airline also said in August that it had more than doubled annual profit to AU$250 million. But it warned the business climate was too unstable to forecast future earnings.

Australian and International Pilots Association president Barry Jackson said its negotiators were working hard to come to a resolution with the airline.

"The clock is ticking," Jackson told Australian Broadcasting Corp. television on Monday night. "I'm pretty confident that we'll get an agreement."

Qantas CEO Alan Joyce defended his decision to ground the airline, saying while it was costly in the short-term, it helped the airline overall.

"I'll make whatever tough decisions are needed to be made in order to ensure the survival of this great company," he said Monday.

Qantas shares were up 3.6 percent to AU$1.67 in Tuesday morning trading on Australia's stock exchange.

Qantas is the 10th-largest airline in the world by passenger miles flown, according to the International Air Transport Association, an airline trade group.

Source: http://us.rd.yahoo.com/dailynews/rss/oceania/*http%3A//news.yahoo.com/s/ap/20111101/ap_on_re_as/as_australia_qantas

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